myasthenia gravis is a neuromuscular disease in which weakness and fatiguability of muscle occur.It is autoimmune disorder.
symptoms-onset of disorder can be sudden.symptoms are intermittent.symptoms like double vision-drooping of one/both eyelids-weakness in arm,hand,finger,legs,neck-change in facial expression-difficulty in swalloing-shortness of breath-impaired speech.
Diagnosis-
by physical examination-tests for muscle fatiguability
1 looking upward and sideward for 30 seconds.
2 looking at feet while lying on back for 60 sec.
3 keeping arm stretched forward for 60 sec.
4 10 deep knee bends
5 walking 30 steps on both toes and heels.
6 5 situps,lying down and sitting up completely.
2 blood test-if diagnosis is suspected serology can be performed in blood to identify antibodies.
3 neurophysiology-EMG
4 endrophonium test-a chest x-ray,CT-scan,MRI
5 pathological findings
Treatment-
cholinesterase inhibiter and immunosuprresent drugs to reduce autoimmune process
or surgery